Increased expression of immune-related genes in leukocytes of patients with diagnosed gestational diabetes mellitus (GDM)

This study demonstrates that an impaired glucose metabolism in GDM may be predominant predictor of leukocyte NOS2 and SFTPD overexpression in diabetic patients. Furthermore, alterations in the expression of these genes are associated with glucose metabolism dysfunction and/or inflammation during pregnancy. In addition, these findings support the utilization of leukocytes as good experimental model to study a relationship between immune-related genes and metabolic changes in women with GDM, as well as to assess the potential mechanisms underlying these alterations.
Source: Experimental Biology and Medicine - Category: Research Authors: Tags: Biochemistry & amp;amp; Molecular Biology Source Type: research