Ophthalmic immunoglobulin G4-related disease IgG4-RD Current concepts

IgG4-related disease (IgG4-RD) is a distinct entity that frequently occurs in an ophthalmic location. As such, IgG4-RD is not limited to the orbit but may also involve other anatomical structures in and around the eye. Hence, the term ‘ophthalmic IgG4-RD’ is preferred over ‘orbital IgG4-RD.’ A high level of suspicion for the diagnosis can be derived from careful clinicoradiologic examination; the use of immunohistochemical staining for IgG4 in the context of characteristic histopathologic features is needed to reach a correct diagnosis.

Source: Seminars in Diagnostic Pathology - October 6, 2015 Category: Pathology Authors: Kaustubh Mulay, Mark R. Wick Source Type: research