Alternate-day fasting protects the livers of mice against high-fat diet-induced inflammation associated with the suppression of TLR-4/NF-κB signaling

Due to unhealthy lifestyles, a large number of people are suffering from hepatic lipid accumulation and nonalcoholic steatohepatitis. Calorie restriction (CR) is an effective nutritional intervention for preventing chronic disease. However, poor compliance with continuous calorie restriction limits its effectiveness. As an alternative to daily CR, alternate-day fasting (ADF) may be more effective. We hypothesized that ADF would improve obesity, hyperglycemia and insulin resistance and protect the liver against high-fat (HFD) diet-induced steatosis and inflammation.

Source: Nutrition Research - February 16, 2016 Category: Nutrition Authors: Wanwei Yang, Meng Cao, Xiaodong Mao, Xiao Wei, Xingjia Li, Guofang Chen, Jiaming Zhang, Zhiguo Wang, Jianfeng Shi, HouCai Huang, Xiaoming Yao, Chao Liu Source Type: research