Restricted ROC curves are useful tools to evaluate the performance of tumour markers

In this study, a new statistical approach is proposed to perform this task. Furthermore, a statistical test associated with the area under a ROC curve corresponding to informative values only (restricted ROC curve) is provided and its properties are explored by extensive simulations. Finally, the proposed method is applied to a real data set containing peripheral blood levels of six tumour markers proposed for the diagnosis of neuroblastoma. A new approach to combine couples of markers for classification purposes is also illustrated.

Source: Statistical Methods in Medical Research - February 16, 2016 Category: Statistics Authors: Parodi, S., Muselli, M., Carlini, B., Fontana, V., Haupt, R., Pistoia, V., Corrias, M. Tags: Articles Source Type: research