Interaction between MTHFR 677C>T and periconceptional folic acid supplementation in the risk of Hypospadias

ConclusionOur study does not suggest a major role for folic acid supplements or the MTHFR C677T polymorphism in the etiology of hypospadias in general, but not using folic acid and/or carrying the MTHFR C677T polymorphism may be associated with middle and posterior hypospadias. Therefore, we stress the importance of studying gene–environment interactions preferably in stratified analyses for different hypospadias phenotypes. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc.

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - February 16, 2016 Category: Perinatology & Neonatology Authors: Elisabeth M.J. Dokter, Iris A.L.M. van Rooij, Charlotte H.W. Wijers, Johanne M. Groothuismink, Jan Jaap van der Biezen, Wout F.J. Feitz, Nel Roeleveld, Loes F.M. van der Zanden Tags: Original Research Article Source Type: research