LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function

In conclusion, our longitudinal deep-phenotyping provides novel insights into how the genetic burden arising from human mutant LRRK2 manifests as early pathophysiological changes to dopamine circuit function and highlights a potential model for testing Parkinson's therapeutics.

Source: Human Molecular Genetics - February 15, 2016 Category: Genetics & Stem Cells Authors: Sloan, M., Alegre-Abarrategui, J., Potgieter, D., Kaufmann, A.-K., Exley, R., Deltheil, T., Threlfell, S., Connor-Robson, N., Brimblecombe, K., Wallings, R., Cioroch, M., Bannerman, D. M., Bolam, J. P., Magill, P. J., Cragg, S. J., Dodson, P. D., Wade-Mar Tags: ARTICLES Source Type: research