Inactivation of CYP3A4 by Benzbromarone in Human Liver Microsomes

Conclusion: Modification of the P450 enzyme by the reactive metabolite is a common trait of drugs that induce idiosyncratic hepatotoxicity, and might provide a speculative, mechanistic model for the rare occurrences of this type of drug toxicity.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research