Mechanism of Developmental Effects in Rats Caused by an N‐Phenylimide Herbicide: Transient Fetal Anemia and Sequelae during Mid‐to‐Late Gestation

ConclusionWe propose that developmental toxicity results from PPO inhibition in primitive erythroblasts, causing transient fetal anemia followed by death. Compensatory enlargement of the fetal heart results in failure of interventricular foramen closure and VSD. Reduced serum protein leads to delayed ossification and wavy ribs

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 1, 2015 Category: Perinatology & Neonatology Authors: Satoshi Kawamura, Takafumi Yoshioka, Nobuaki Mito, Noriyuki Kishimoto, Masanao Nakaoka, Alan G. Fantel Tags: Research Article Source Type: research