Small molecule tolfenamic acid and dietary spice curcumin treatment enhances anti-proliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution

The objective of this study was to identify agent with low toxicity and COX-independent mechanism to induce PC cell growth inhibition when used along with Cur. Anti-cancer NSAID, Tolfenamic acid (TA) and Cur combination was evaluated using PC cell lines. L3.6pl and MIA PaCa-2 cells were treated with Cur (5-25 μM) or TA (25-100 μM) or combination of Cur (7.5 μM) and TA (50 μM).

Source: The Journal of Nutritional Biochemistry - February 10, 2016 Category: Biochemistry Authors: Riyaz Basha, Sarah F. Connelly, Umesh T. Sankpal, Ganji Purnachandra Nagaraju, Hassaan Patel, Jamboor K. Vishwanatha, Sagar Shelake, Leslie Tabor-Simecka, Mamoru Shoji, Jerry W. Simecka, Bassel El-Rayes Source Type: research