Efficacy and toxicity of salvage weekly paclitaxel chemotherapy in non-Asian patients with advanced oesophagogastric adenocarcinoma

Conclusions:
OGA cancer patients treated at RMH with salvage paclitaxel had an OS equivalent to patients in clinical trials with more (33%) PS = 2 patients treated and less haematological toxicity than Asian patients. Eastern Cooperative Oncology Group (ECOG) PS more than or equal to 2, ALP more than or equal to 100 U/L, and prior platinum rechallenge were associated with poor survival. However, the proportion of patients surviving more than or equal to two years from diagnosis demonstrates a clinically relevant improvement from historical controls.

Source: Therapeutic Advances in Medical Oncology - February 11, 2016 Category: Cancer & Oncology Authors: Tarazona, N., Smyth, E. C., Peckit, C., Chau, I., Watkins, D., Rao, S., Starling, N., Cunningham, D. Tags: Original Research Source Type: research