Potential Role for YB-1 in Castration-Resistant Prostate Cancer and Resistance to Enzalutamide Through the Androgen Receptor V7

Conclusions:
YB-1 appears to be a promising target to inhibit the development of castration resistance, even at the AR variant–expressing stage. Polymorphism in the YB-1 gene may be a promising predictive biomarker in hormonal therapy.

Source: JNCI - February 8, 2016 Category: Cancer & Oncology Authors: Shiota, M., Fujimoto, N., Imada, K., Yokomizo, A., Itsumi, M., Takeuchi, A., Kuruma, H., Inokuchi, J., Tatsugami, K., Uchiumi, T., Oda, Y., Naito, S. Tags: Article Source Type: research