Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways

Conclusions:
Our findings suggest a role of IRF4 rs12203592 in pathway-specific risk for melanoma development. We hypothesize that IRF4 rs12203592 could underlie in part the bimodal age distribution reported for melanoma and linked to the divergent pathways.

Source: JNCI - February 8, 2016 Category: Cancer & Oncology Authors: Gibbs, D. C., Orlow, I., Bramson, J. I., Kanetsky, P. A., Luo, L., Kricker, A., Armstrong, B. K., Anton-Culver, H., Gruber, S. B., Marrett, L. D., Gallagher, R. P., Zanetti, R., Rosso, S., Dwyer, T., Sharma, A., La Pilla, E., From, L., Busam, K. J., Cust, Tags: Article Source Type: research