Pre-leukemic Phase of Chronic Myelogenous Leukemia: Morphologic, and Immunohistochemical Characterization of Seven Cases

Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm that originates from a pluripotent bone marrow stem cell. The small derivative of chromosome 22, known as the Philadelphia chromosome (Ph), is generated by the t(9;22)(q34;q11.2) and produces a BCR-ABL1 fusion gene. This abnormality is disease-defining for CML in the context of a myeloproliferative neoplasm [1]. (See Figs. 1– 3.) (See Tables 1–3.)

Source: Annals of Diagnostic Pathology - February 5, 2016 Category: Pathology Authors: Le Le Aye, Sanam Loghavi, Ken H. Young, Imran Siddiqi, C. Cameron Yin, Mark J. Routbort, Mei Liang, Keith Eilerman, L. Jeffrey Medeiros, Russell K. Brynes, Carlos Bueso-Ramos Source Type: research