Pertinence des marqueurs sériques du premier trimestre pour prédire les complications de la grossesse : étude prospective tunisienne

Conclusion Les marqueurs sériques du premier trimestre semblent avoir une bonne valeur prédictive des complications adverses de la grossesse. Un modèle de prédiction de risque pourrait être conçu à partir de ces marqueurs et en associant des caractéristiques maternelles et échographiques afin de cibler en prophylaxie une population à risque. Objectives Identify applications and utility of serum markers dosed in the first trimester in predicting, early diagnosis and management of various complications of pregnancy. Methods Eight hundred and eighty patients were included in this prospective regional study performed in the governorate of Bizerte in northern Tunisia in collaboration between the private and public sectors. Serum markers of the first quarter, PAPP A and βhCG, were measured in the same laboratory. The performance of these markers was studied in the prediction of adverse pregnancy complications. Results The prevalence of various pregnancy complications was 8.6% for birth prematurely, 9.2% for hypertension or preeclampsia, IUGR 5.8% and 7.3% for loss pregnancy. PAPP A levels were lower in fetal loss group (P =0.005), vascular disease group (P =0.001) and preterm delivery group (P =0.001). In addition, a lower rate of βhCG was associated with the occurrence of placental pathologies such as growth retardation (P =0.037) and hypertension (P =0.034) and appears to have no predictive value in the occurrence of preterm birth (P =0.76) and fetal loss (P =...
Source: Gynecologie Obstetrique and Fertilite - Category: OBGYN Source Type: research