Selective inhibition of tumor cell associated Vacuolar-ATPase ‘a2’ isoform overcomes cisplatin resistance in ovarian cancer cells

Development of resistance to platinum compounds significantly hinders successful ovarian cancer (OVCA) treatment. In tumor cells, dysregulated pH gradient across cell membranes is a key physiological mechanism of metastasis/chemo-resistance. These pH alterations are mediated by aberrant activation of key multi-subunit proton pumps, Vacuolar-ATPases (V-ATPases). In tumor cells, its ‘a2’ isoform (V-ATPase-V0a2) is a component of functional plasma–membrane complex and promotes tumor invasion through tumor-acidification and immuno-modulation.

Source: Molecular Oncology - January 28, 2016 Category: Cancer & Oncology Authors: Arpita Kulshrestha, Gajendra K. Katara, Jordyn Ginter, Sahithi Pamarthy, Safaa A. Ibrahim, Mukesh K. Jaiswal, Corina Sandulescu, Ramayee Periakaruppan, James Dolan, Alice Gilman-Sachs, Kenneth D. Beaman Source Type: research