Decidual soluble factors, through modulation of dendritic cells functions, determine the immune response patterns at the feto-maternal interface

Many different mechanisms acting locally or at a distance ensure tolerance of the semi-allogeneic fetus by the maternal innate and adaptive immune defenses (Koch and Platt, 2003). In contrast to this tolerance, some mechanisms exist that ensure the rejection of the fetus by the mother (spontaneous abortion) through the failure of one or more tolerance induction mechanisms. It has been proposed that local immunoregulatory factors present at the fetomaternal interface help to maintain fetal tolerance (Guleria and Sayegh, 2007).
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research