MiR-302a/b/c/d cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein(P-gp) by targeting MAP/ERK kinase kinase 1 (MEKK1)

Conclusion: Our results indicate that miR-302 cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein by targeting MEKK1 of ERK pathway. miR-302 gene cluster may be a potential target for reversing P-gp-mediated chemoresistance in breast cancer.

http://www.jeccr.com/content/35/1/25

Source: Epidemiologic Perspectives and Innovations - February 3, 2016 Category: Epidemiology Authors: Lin ZhaoYan WangLongyang JiangMiao HeXuefeng BaiLifeng YuMinjie Wei Source Type: research