Are the Symptoms of Calcific Tendinitis Due to Neoinnervation and/or Neovascularization?

Conclusions: This is the first study to show a significant increase in neovascularization and neoinnervation in calcific tendinitis lesions of the shoulder along with an eightfold increase in mast cells and macrophages. The findings are consistent with the hypothesis that, in calcific tendinitis, the calcific material is inducing a vigorous inflammatory response within the tendon with formation of new blood vessels and nerves. Clinical Relevance: This study helps to explain why calcific tendinitis is related to substantial pain in the clinical setting.
Source: The Journal of Bone and Joint Surgery - Category: Orthopaedics Authors: Tags: Basic Science, Shoulder Scientific Articles Source Type: research