L’infertilité est-elle un facteur de risque de cancer du sein ? Revue actualisée de la littérature et méta-analyse

Conclusion L’infertilité ne constitue pas un facteur de risque identifié de cancer du sein. Un message rassurant devrait être délivré à ces patientes. En dehors de situations à haut risque mammaire, l’infertilité ne constitue pas une indication de surveillance sénologique accrue. The objective of this review was to assess the level of risk of breast cancer of patients consulting for infertility. Methods Studies of cohorts and case-control were extracted from the Pubmed database from January 2000 until May 2015 through the following keywords: “infertility”; “endometriosis”; “polycystic ovary syndrome”; “breast cancer”, “cancer risk”. Eleven publications were finally selected after exclusion of publications dealing with infertility after breast cancer. Our meta-analysis, involving 10 of these publications, was performed using Review Manager software, Cochrane Collaboration, 2014. The results were calculated by etiology of infertility, polycystic ovary syndrome (PCOS) and endometriosis, as well as globally. Results The analysis of these published epidemiological studies confirms that infertility is not a breast cancer risk factor, but the results are contradictory. Three studies have shown a significantly increased risk of breast cancer in a population of infertile women, while 7 others have not found this risk. These contradictions are due to the heterogeneity of the studies, the included populations, the follow-up periods and confoundi...
Source: Gynecologie Obstetrique and Fertilite - Category: OBGYN Source Type: research