DNA, the central molecule of aging

Publication date: Available online 2 February 2016 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Peter Lenart, Lumir Krejci Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes.

Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 2, 2016 Category: Cytology Source Type: research