A Randomized Controlled Trial to evaluate the Lung Clearance Index as an Outcome Measure for Early Phase Studies in patients with Cystic Fibrosis

Outcome measures that can evaluate treatment efficacy are important to enhance development of new therapeutic agents for Cystic Fibrosis (CF). We investigated whether the lung clearance index (LCI) measured by multiple breath washout (MBW) can detect a treatment effect of hypertonic saline (HS) inhalation after single dosing within a 24 hour period.

Source: Respiratory Medicine CME - February 1, 2016 Category: Respiratory Medicine Authors: Reshma Amin, Sanja Stanojevic, Mica Kane, Hailey Webster, Felix Ratjen Source Type: research