Gum arabic suppressed diet-induced obesity by alteration the expression of mRNA levels of genes involved in lipid metabolism in mouse liver

Publication date: Available online 28 January 2016 Source:Bioactive Carbohydrates and Dietary Fibre Author(s): Abdelkareem A. Ahmed, Hassan H. Musa, Jafaar S. Fedail, Amal Z. Sifaldin, Taha H. Musa Obesity is a global health concern associated with high morbidity and mortality. Therapeutic strategies include surgery and synthetic drugs; however, these may cause severe complications and high costs. The anti-obese effects of dietary fiber have widely been accepted in literature. Gum arabic (GA, Acacia Senegal) considered as a dietary fiber that could reduce the body fat deposition, nevertheless, its anti-obese effects remained unclear. In the present study, we fed mice either a normal diet (control), low fat diet (low), high-fat diet (high) or a high-fat diet supplemented with 10% w/w GA (High+gum) for 12 weeks. Body weights, visceral adipose tissue (VAT), plasma lipid profile, blood glucose and lipid metabolic genes expressions were measured. GA supplementation significantly decreased (P<0.01) VAT, blood glucose, LDL, VLDL and total cholesterol, whereas, increased HDL concentrations. However, GA supplementation did not alter plasma triglycerides. Likewise, the supplementation of GA did not change lipogenic gene expression including fatty acid synthetase (FAS), stearoyl-coa desaturase (SCD) and acetyl-CoA carboxylase (ACC). Likewise, GA did not affect the expression of monoacylglycerol lipase (MGL), peroxisome proliferators activated receptor-γ (PPAR-γ) a...
Source: Bioactive Carbohydrates and Dietary Fibre - Category: Food Science Source Type: research