Current topics in HIV pathogenesis, part 2: Inflammation drives a Warburg-like effect on the metabolism of HIV-infected subjects

Today, the immuno-metabolism is the heart of an ever growing body of studies, spanning the fields of cancer, auto-immunity, metabolic disorders and infections. This renaissance in the field of metabolism stands on the shoulders of biochemists like Warburg and Krebs, who spent their professional life exploring the intricacies of cell metabolism and the relationship between metabolism, innate immunity and inflammation [1,2]. As humans evolved, the two strongest selection determinants of survival combined a robust immune response able to clear microbes with ability to efficiently store nutrients to survive times when food was scarce [3].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research