Urinary Metabolic Profile Predicts High Fat Diet Sensitivity in the C57Bl6/J mouse

To prevent the development of adiposity associated metabolic diseases, early biomarkers are needed. Such markers could bring insight to understand the complexity of susceptibility to obesity. Urine and plasma metabolomics fingerprints have been successfully associated with metabolic dysfunctions. Fat resistance (FR) was found to be associated with higher urinary levels of acylglycines and leucine. However, no differences were observed before the diet switch. In this context, we aimed at characterizing metabolic signatures predictive of resistance or sensitivity to fat in the C57Bl6/J mouse model.

Source: The Journal of Nutritional Biochemistry - January 27, 2016 Category: Biochemistry Authors: Juliette Fedry, Anne Blais, Patrick C. Even, Julien Piedcoq, Gilles Fromentin, Claire Gaudichon, Dalila Azzout-Marniche, Daniel Tomé Source Type: research