Thyroid hormone receptor-{alpha} deletion decreases heart function and exercise performance in apolipoprotein E-deficient mice

In conclusion, the deletion of TRα in ApoE–/– mice alters cardiac structure and contractility; both could contribute to blunted BP response to physical exercise and impaired exercise performance.

Source: Physiological Genomics - January 27, 2016 Category: Genetics & Stem Cells Authors: Liu, K. L., Canaple, L., del Carmine, P., Gauthier, K., Beylot, M., Lo, M. Tags: Call for Papers: Systems Biology and Polygenic Traits Source Type: research