The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis

Conclusions: These findings suggest a new therapeutic paradigm for preventing breast cancer metastasis. Pro-malignant signals from the tumor microenvironment with long-lasting effects on associated cancer cells may perpetuate the metastatic potential of developing cancers. Inhibition of these microenvironment signals represents a new therapeutic strategy against cancer metastasis that enables targeting of stromal cells with less genetic plasticity than associated cancer cells and opens new avenues for investigation of novel therapeutic targets and agents.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research