Controlled Dual Growth Factor Delivery From Microparticles Incorporated Within Human Bone Marrow-Derived Mesenchymal Stem Cell Aggregates for Enhanced Bone Tissue Engineering via Endochondral Ossification
This study demonstrates the regulation of chondrogenesis and osteogenesis with regard to endochondral bone formation in high-density stem cell systems through the controlled presentation of inductive factors from incorporated microparticles. This work lays the foundation for a rapidly implantable tissue engineering system that promotes bone repair via endochondral ossification, a pathway that can delay the need for a functional vascular network and has an intrinsic ability to promote angiogenesis. The modular nature of this system lends well to using different cell types and/or growth factors to induce endochondral bone formation, as well as the production of other tissue types.
Source: Stem Cells Translational Medicine - Category: Stem Cells Authors: Dang, P. N., Dwivedi, N., Phillips, L. M., Yu, X., Herberg, S., Bowerman, C., Solorio, L. D., Murphy, W. L., Alsberg, E. Tags: Tissue Engineering and Regenerative Medicine, Mesenchymal Stem Cells Source Type: research