Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-{beta} Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac Differentiation

This study demonstrates how differentiation of induced pluripotent stem cells can be used to identify and isolate cell populations of interest that can translate to the adult human heart. Two separate examples of phenotypic screens are discussed, demonstrating the value of this biologically relevant and reproducible technology. In addition, this assay system was able to identify novel and potent inducers of differentiation and proliferation of induced pluripotent stem cell-derived cardiac progenitor cells.

Source: Stem Cells Translational Medicine - January 27, 2016 Category: Stem Cells Authors: Drowley, L., Koonce, C., Peel, S., Jonebring, A., Plowright, A. T., Kattman, S. J., Andersson, H., Anson, B., Swanson, B. J., Wang, Q.-D., Brolen, G. Tags: Cell-Based Drug Development, Screening, and Toxicology, Pluripotent Stem Cells, Cardiac Stem Cells Source Type: research