Treatment of Chronic Bone Infections

The treatment of chronic osteomyelitis (COM) depends on the obstinate persistence of the offending microorganism(s), and can result in long-term patient disability that increases costs to the health care system. Difficulties of treating COM derive from biofilm-forming pathogens that resist the host immunological defense and other antimicrobial substances, and the need to treat osseous defects that result from the disease itself. Established surgical techniques require multiple costly operations with extended periods of disablement and impairment of the patients, sometimes making the therapy worse than the disease.

Source: Operative Techniques in Orthopaedics - January 26, 2016 Category: Orthopaedics Authors: Heinz Winkler Source Type: research