Immunoglobulin M deficiency in clozapine‐treated patients

The atypical antipsychotic clozapine has demonstrated effectiveness in managing patients with treatment‐resistant schizophrenia. However, the drug also affects levels of antibody‐producing cytokines and possesses immunosuppressive activity, and therefore could affect humoral immunity.1 A recent report investigated the relationship between long‐term clozapine treatment and the occurrence of selective immunoglobulin M deficiency, a rare dysgammaglobulinemia that occurs in the setting of normal T‐cell number.2

Source: The Brown University Psychopharmacology Update - January 25, 2016 Category: Psychiatry Authors: Y. W. Francis Lam Tags: Drug ‐Drug Interactions Source Type: research