A Fluorescent Oligothiophene-Bis-Triazine ligand interacts with PrP fibrils and detects SDS-resistant oligomers in human prion diseases
Conclusions:
MR100 is a powerful tool not only for studying the prion aggregation pathways regarding oligomeric and sPrP
Sc
species, but also for developing alternative methods for the detection of prion-infected samples. Considering our bioassay results, MR100 is a promising molecule for the development of prion decontamination approaches.
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Thibaut ImberdisAdeline Ayrolles-TorroAlysson Duarte RodriguesJoan TorrentMaria Alvarez-MartinezGabor KovacsJean-Michel VerdierMike RobitzerVĂ©ronique Perrier Source Type: research