CXCL12 Gene Therapy Ameliorates Ischemia-Induced White Matter Injury in Mouse Brain

This study has demonstrated for the first time that CXCL12 gene therapy significantly ameliorates brain ischemia-induced white matter injury and promotes oligodendrocyte progenitor cell proliferation in the subventricular zone and migration to the perifocal area in the ischemic mouse brain. Additional data showed that CXCR4 receptor plays an important role during the proliferation and migration of oligodendrocyte progenitor cells, and CXCR7 might play a role during maturation. In contrast to many experimental studies that provide treatment before ischemic insult, CXCL12 gene therapy was performed 1 week after brain ischemia, which significantly prolonged the therapeutic time window of brain ischemia.

Source: Stem Cells Translational Medicine - September 17, 2015 Category: Stem Cells Authors: Li, Y., Tang, G., Liu, Y., He, X., Huang, J., Lin, X., Zhang, Z., Yang, G.-Y., Wang, Y. Tags: Tissue-Specific Progenitor and Stem Cells, Neural/Progenitor Stem Cells Source Type: research