Structural Changes in N-Glycans on Induced Pluripotent Stem Cells Differentiating Toward Cardiomyocytes

This study focused on N-glycans produced in human induced pluripotent stem cells (iPSCs) and iPSC-derived cardiomyocytes to investigate their change on cardiomyogenic differentiation in vitro. This shows that the expression pattern of N-glycans in human iPSCs changed toward the pattern observed in human cardiomyocytes upon cardiomyogenic differentiation. Structural differences were also observed in the bisecting N-acetylglucosamine and the triantennary structures upon cardiomyogenic differentiation. The findings of this study will help in understanding the directional precision of cardiomyogenic differentiation in vitro.

Source: Stem Cells Translational Medicine - October 27, 2015 Category: Stem Cells Authors: Kawamura, T., Miyagawa, S., Fukushima, S., Kashiyama, N., Kawamura, A., Ito, E., Saito, A., Maeda, A., Eguchi, H., Toda, K., Miyagawa, S., Okuyama, H., Sawa, Y. Tags: Pluripotent Stem Cells, Cardiac Stem Cells Source Type: research