Solution-Phase Crosstalk and Regulatory Interactions Between Multipotent Adult Progenitor Cells and Peripheral Blood Mononuclear Cells

This study documents experiments quantifying solution-phase crosstalk between multipotent adult progenitor cells (MAPCs) and peripheral blood mononuclear cells. The secretome and transcriptional changes quantified suggest mechanisms by which MAPCs are hypothesized to provide both local and systemic immunoregulation of inflammation. The potential impact of these studies includes development of a robust experimental framework to be used for preclinical evaluation of the specific mechanisms by which beneficial effects are obtained after treatment of patients with MAPCs.

Source: Stem Cells Translational Medicine - December 10, 2015 Category: Stem Cells Authors: Burrows, G. G., vant Hof, W., Reddy, A. P., Wilmarth, P. A., David, L. L., Raber, A., Bogaerts, A., Timmerman, L., Pinxteren, J., Roobrouck, V. D., Deans, R. J., Maziarz, R. T. Tags: Tissue-Specific Progenitor and Stem Cells, Mesenchymal Stem Cells Source Type: research