Hypothermia associated with clobazam use in adult epilepsy

Publication date: Available online 20 January 2016 Source:Epilepsy & Behavior Case Reports Author(s): Angela C. Gauthier, Imran H. Quraishi, Richard H. Mattson Clobazam, a 1,5-benzodiazepine FDA approved in 2011, is commonly used to treat anxiety and epilepsy. It has never been associated with hypothermia until very recently, in a case report involving two pediatric patients. Here, we report the first case of hypothermia development in an adult epileptic patient associated with clobazam use. A couple months after starting clobazam, the patient started developing episodes of hypothermia every several weeks, with temperatures ranging from 90° F – 95° F. Normothermia was achieved with Bair Hugger therapy. TSH and cortisol levels were normal, and there was no evidence of infection in most instances. After 11 total episodes of hypothermia over a year of clobazam use, the drug was discontinued. It has now been 7months after discontinuation, and the patient has not experienced any more episodes of hypothermia. Early recognition of the link between clobazam and hypothermia may prevent many avoidable Emergency Department visits and hospitalizations.

Source: Epilepsy and Behavior Case Reports - January 20, 2016 Category: Neurology Source Type: research