Mechanisms of glyceryl trinitrate provoked mast cell degranulation

Conclusions
Direct application of an exogenous nitric oxide donor on dural mast cells does not cause mast cell degranulation ex vivo. In vivo application of the nitric oxide donor glyceryl trinitrate leads to a prominent level of degranulation via a yet unknown mechanism. This effect can be completely blocked by inhibition of the endogenous nitric oxide production and by 5-HT1B/1D receptor agonists but is unaffected by calcitonin gene-related peptide and substance P receptor antagonists.

Source: Cephalalgia - November 16, 2015 Category: Neurology Authors: Pedersen, S. H., Ramachandran, R., Amrutkar, D. V., Petersen, S., Olesen, J., Jansen-Olesen, I. Tags: Original Articles Source Type: research