White matter microstructure abnormalities in pediatric migraine patients

Conclusions Pediatric migraine patients harbor diffuse brain WM microstructural abnormalities. High FA and low MD, AD and RD in these patients might be explained by repeated neuronal activation, which may lead to cell swelling and stimulate activity-dependent myelin-modulation, or by increased fiber and dendritic densities. Both these mechanisms might reflect a hyperexcitability of the brain in migraineurs.

http://cep.sagepub.com/cgi/content/abstract/35/14/1278?rss=1

Source: Cephalalgia - November 16, 2015 Category: Neurology Authors: Messina, R., Rocca, M. A., Colombo, B., Pagani, E., Falini, A., Comi, G., Filippi, M. Tags: Original Articles Source Type: research