The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2

Lafora disease (LD, OMIM 254780) is a fatal neurodegenerative disorder produced mainly by mutations in two genes: EPM2A, encoding the dual specificity phosphatase laforin, and EPM2B, encoding the E3-ubiquitin lig...

Source: BMC Biochemistry - October 23, 2015 Category: Biochemistry Authors: Rosa Viana, Pablo Lujan and Pascual Sanz Source Type: research