miR‐1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K‐ras in nasopharyngeal carcinoma

In this study we found that restoration of miR‐1 dramatically inhibited cell invasion in vitro, together with tumour growth and metastasis in vivo. Importantly, we found that LMP1, an Epstein–Barr virus (EBV)‐associated protein, suppressed miR‐1 expression. Furthermore, we identified K‐ras as a novel direct target of miR‐1. Our results demonstrated for the first time that miR‐1 was suppressed by LMP1 and its tumour‐suppressive effects were mediated chiefly by repressing K‐ras expression. We propose that miR‐1 could serve as an independent biomarker to identify patients with different clinical characteristics.

Source: International Journal of Experimental Pathology - January 19, 2016 Category: Pathology Authors: Xi Chen, Jingxuan Shi, Jianwen Zhong, Zhenyun Huang, Xi Luo, Yaping Huang, Shuang Feng, Jianbo Shao, Dabo Liu Tags: Original Article Source Type: research