Haploidentical Stem Cell Transplantation: Anti-thymocyte Globulin-Based Experience

Haploidentical stem cell transplantation (haplo-SCT) with an anti-thymocyte globulin (ATG) preparative regimen is associated with induced immune tolerance, rapid hematopoietic recovery, effective prevention of graft-versus-host disease (GVHD), and lower NRM. This has become a common and successfully applied protocol in patients with hematological diseases undergoing haplo-SCT. Survival rates among patients who undergo unmanipulated haploidentical blood and marrow transplantation (HBMT) with ATG-based regimens are comparable to those following human leukocyte antigen-matched sibling transplantation or unrelated donor transplantation.
Source: Seminars in Hematology - Category: Hematology Authors: Source Type: research