Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

Conclusions: Our results demonstrate that WAP-Cre:Pten f/f :p53 lox.stop.lox_R270H mice represent a tractable model to study basal-like breast cancer because unlike p53 deletion, p53 R270H mutation in the mouse does not skew tumors toward the claudin-low subtype. The WAP-Cre:Pten f/f :p53 lox.stop.lox_R270H mice develop basal-like breast cancer that is enriched in TICs, can readily form lung metastasis, and provides a preclinical model to study both basal-like and claudin-low TNBC in immune-competent mice.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research