Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer
Conclusions:
Our results demonstrate that WAP-Cre:Pten
f/f
:p53
lox.stop.lox_R270H
mice represent a tractable model to study basal-like breast cancer because unlike p53 deletion, p53
R270H
mutation in the mouse does not skew tumors toward the claudin-low subtype. The WAP-Cre:Pten
f/f
:p53
lox.stop.lox_R270H
mice develop basal-like breast cancer that is enriched in TICs, can readily form lung metastasis, and provides a preclinical model to study both basal-like and claudin-low TNBC in immune-competent mice.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Sharon WangJeff LiuDanbi KimAlessandro DattiEldad Zacksenhaus Source Type: research
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