Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype

Publication date: Available online 16 January 2016 Source:EuPA Open Proteomics Author(s): Laura Giusti, Federica Ciregia, Alessandra Bonotti, Ylenia Da Valle, Elena Donadio, Claudia Boldrini, Rudy Foddis, Gino Giannaccini, Maria R. Mazzoni, Pier Aldo Canessa, Alfonso Cristaudo, Antonio Lucacchini Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes. Graphical abstract
Source: EuPA Open Proteomics - Category: Bioinformatics Source Type: research