Change in Off-Label Use of Bone Morphogenetic Protein in Spine Surgery and Associations with Adverse Outcome

Conclusions Using a previously untapped data source, we show decreased (off-label) BMP-2 use in spinal fusions, particularly in cervical fusions. Although there was a tendency of decreased odds in 2009 to 2012, higher resource utilization and odds for complications remain in patients using BMP-2. A national registry or prospective observational studies will benefit the ongoing discussion.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text

Source: Global Spine Journal - January 15, 2016 Category: Orthopaedics Authors: Poeran, JashvantOpperer, MathiasRasul, RehanaMazumdar, MadhuGirardi, Federico P.Hughes, Alexander P.Memtsoudis, Stavros G.Vougioukas, Vassilios Tags: Original Article Source Type: research