Alternative Donor Transplants for Severe Aplastic Anemia: Current Experience

Patients with acquired severe aplastic anemia (SAA), who lack and HLA identical sibling donor (SIB) , have two therapeutic options: immunosuppressive therapy with anti-thymocyte globulin (ATG) and cyclosporine (CsA), or a transplant from an alternative donor. In these patients, current guidelines of the European Group for Blood and Marrow Transplantation (EBMT), call for a course of ATG+CsA first and transplantation in case of no response. The alternative donor can be an unrelated donor (UD), a cord blood Unit (CB) or a family mismatched member, in most instances genetically HLA haplo-mismatched (HAPLO).
Source: Seminars in Hematology - Category: Hematology Authors: Source Type: research