Supportive Care in Alternative Donor Transplantation

Alternative donor hematopoietic cell transplantation (HCT) using umbilical cord blood, haploidentical or mismatched unrelated donors is a viable option for patients without HLA-identical sibling or matched unrelated donors. The same principles of supportive care as conventional graft sources apply to alternative donor HCT recipients. However, there are some unique supportive care issues related to post-transplant complications, engraftment, graft-versus-host disease, immune reconstitution and infections that are unique to each of the three alternative graft sources, both in the early and late post-transplant period.

Source: Seminars in Hematology - January 15, 2016 Category: Hematology Authors: Shuang Fu, Navneet S. Majhail Source Type: research