Haploidentical Transplantation: Selecting Optimal Conditioning Regimen and Stem Cell Source

Recently, haploidentical donor transplant (HIDT) has emerged as a viable option for patients in need of an allogeneic stem cell transplant without an immediately available well-matched human leukocyte antigen (HLA) sibling or unrelated donor. Given the near immediate availability of haploidentical donors, along the high likelihood of a haploidentical match within a patient’s first degree family, HIDT is becoming increasing attractive, particularly for patients with high risk disease. In the last decade, several strategies of T-cell replete bone marrow or peripheral blood HIDT has been developed with diverse conditioning regimens and graft-versus-host disease prophylaxis based on diverse in vivo T cell modulation strategies conducting to a wide development for the treatment of benign and malignant hematological disorders.
Source: Seminars in Hematology - Category: Hematology Authors: Source Type: research