Transplantations from HLA-identical Siblings Versus 10/10 HLA-matched Unrelated Donors

The clinical outcome after allogeneic stem cell transplantation from an HLA-matched sibling donor as well as an HLA-matched unrelated donor has clearly improved due in part to the progress made in the domains of HLA-typing techniques. Although HLA-matched sibling transplantation is still held as the “gold standard,” transplantation from HLA-A, -B, -C, -DRB1, and -DQB1-matched unrelated donors (so called 10/10) represent the first choice for patients without a suitable related donor. Several studies have shown that unmanipulated marrow transplantation from an HLA allele-matched unrelated donor resulted in similar outcomes to those observed following sibling transplantation.
Source: Seminars in Hematology - Category: Hematology Authors: Source Type: research