The effect of oligo(trimethylene carbonate) addition on the stiffness of acrylic bone cement.

The effect of oligo(trimethylene carbonate) addition on the stiffness of acrylic bone cement. Biomatter. 2016 Jan 4;:0 Authors: Persson C, López A, Fathali H, Hoess A, Rojas R, Ott MK, Hilborn J, Engqvist H Abstract With the increasing elderly population an increase in the number of bony fractures associated to age-related diseases such as osteoporosisalso follows. The relatively high stiffness of the acrylic bone cements used in these patients has been suggested to give raise to a suboptimal load distribution surrounding the cement in vivo, and hence contribute to clinical complications, such as additional fractures. The aim of this study was to develop a low-modulus bone cement, based on currently used, commercially available poly(methyl methacrylate) (PMMA) cements for vertebroplasty. To this end, acrylate end-functionalized oligo(trimethylene carbonate) (oTMC) was incorporated into the cements, and the resulting compressive mechanical properties were evaluated, as well as the cytotoxic and handling properties of selected formulations. 16 wt%oTMC was needed in the vertebroplastic cement Osteopal V to achieve an elastic modulus of 1063 MPa (SD 74), which gave a corresponding compressive strength of 46.1 MPa (SD 1.9). Cement extracts taken at 1 and 12 hours gave a reduced MG-63 cell viability in most cases, while extracts taken at 24 hours had no significant effect on cell behaviour. The modification also gave an increase in s...
Source: Biomatter - Category: Biotechnology Tags: Biomatter Source Type: research