Functional conservation of the apoptotic machinery from coral to man: the diverse and complex Bcl-2 and caspase repertoires of Acropora millepora

Conclusions:
The data presented here confirm that many of the basic mechanisms involved in both the intrinsic and extrinsic apoptotic pathways were in place in the common ancestor of cnidarians and bilaterians. With the identification of most or all of the repertoires of coral Bcl-2 and caspases, our results not only provide new perspectives on the evolution of apoptotic pathways, but also a framework for future experimental studies towards a complete understanding of coral bleaching mechanisms, in which apoptotic cell death might be involved.

Source: Epidemiologic Perspectives and Innovations - January 16, 2016 Category: Epidemiology Authors: Aurelie MoyaKazuhiro SakamakiBenjamin MasonLotte HuismanSylvain ForêtYvonne WeissTara BullKentaro TomiiKenichiro ImaiDavid HaywardEldon BallDavid Miller Source Type: research