Carbon dioxide dialysis in a swine model utilizing systemic and regional anticoagulation
Background:
Extracorporeal carbon dioxide removal (ECCO
2
R) has been gaining interest to potentially facilitate gas transfer and equilibrate mild to moderate hypercapnic acidosis, when standard therapy with non-invasive ventilation is deemed refractory. However, concern regarding the effectiveness of low-flow CO
2
removal remains. Additionally, the prospect to steadily reduce hypercapnia via low-flow ECCO
2
R technique is limited, especially with regional anticoagulation which potentially reduces the risk of bleeding. Therefore, an in vivo study was conducted to determine the efficacy of CO
2
removal through a modified renal dialysis unit during the carbon dioxide dialysis study using systemic and regional anticoagulation.
Methods:
The acute study was conducted for 14 h in landrace pigs (51 ± 3 kg). CO
2
removal using a diffusion membrane oxygenator substituting the hemoconcentrator was provided for 6Â h. Blood and gas (100Â % O
2
) flows were set at 200 and 5 L/min, respectively. Anticoagulation was achieved by systemic heparinization (n = 7) or regional trisodium citrate 4 % (n = 7).
Results:
The CO
2
transfer was highest during the initial hour and ranged from 45 to 35Â...
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: A. SharmaP. WeerwindO. BekersE. WoutersJ. Maessen Source Type: research