Carbon dioxide dialysis in a swine model utilizing systemic and regional anticoagulation

Background: Extracorporeal carbon dioxide removal (ECCO 2 R) has been gaining interest to potentially facilitate gas transfer and equilibrate mild to moderate hypercapnic acidosis, when standard therapy with non-invasive ventilation is deemed refractory. However, concern regarding the effectiveness of low-flow CO 2 removal remains. Additionally, the prospect to steadily reduce hypercapnia via low-flow ECCO 2 R technique is limited, especially with regional anticoagulation which potentially reduces the risk of bleeding. Therefore, an in vivo study was conducted to determine the efficacy of CO 2 removal through a modified renal dialysis unit during the carbon dioxide dialysis study using systemic and regional anticoagulation. Methods: The acute study was conducted for 14 h in landrace pigs (51 ± 3 kg). CO 2 removal using a diffusion membrane oxygenator substituting the hemoconcentrator was provided for 6 h. Blood and gas (100 % O 2 ) flows were set at 200 and 5 L/min, respectively. Anticoagulation was achieved by systemic heparinization (n = 7) or regional trisodium citrate 4 % (n = 7). Results: The CO 2 transfer was highest during the initial hour and ranged from 45 to 35Â...
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Source Type: research